A PhD project on Artificial Intelligence aided design of 3D-printing of immunostimulatory implant for cancer T cell therapy is available through a collaboration with University of West London.
Drop Karolina an email with your CV and research statement if you are interested!
T cell therapy is a promising approach in combating certain blood cancers. However, the conventional intravenous delivery of T cells shows limited efficacy against solid tumours. This is primarily attributed to the considerable challenges these cells face in locating, infiltrating and proliferating within the typically immunosuppressive tumour microenvironment following systemic administration.
Implantable biomaterials can potentially enhance T cell therapy outcomes in solid tumours by enabling localised delivery of T cells and immunostimulatory molecules necessary for the maintenance of their function. This PhD project therefore focuses on developing 3D implantable collagen scaffold to facilitate localised delivery of T cell therapy in solid cancers.
Advanced techniques such as 3D bioprinting will be employed to create specific scaffold shapes and sizes. To optimise these scaffolds and ensure T cell viability, various mechanical and physicochemical aspects will be considered. This optimisation will be achieved through machine learning and AI-based framework, which will assess the scaffold properties, evaluate print quality and optimise T cell viability within the 3D printed scaffold. Additionally, the scaffolds will be loaded with microparticles functionalised immunostimulatory biomolecules (cytokines or antibodies) to maintain T cell function and viability in situ.
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